What governs the selectivity and dynamics of intracellular phase separation (membraneless organelles)?

Question: What governs the selectivity and dynamics of intracellular phase separation (membraneless organelles)?
- Keywords:
  organelles
Asked by them20fen to Sally, Mmboyi, Mike, Michael, Jacinta, Gliday, Elkana, Edna, Arnold on 17 Jul 2025.
- Michael Kimwele answered on 17 Jul 2025:
  
  Intracellular phase separation, which governs the formation and dynamics of membraneless organelles, is primarily driven by thermodynamic principles and the strength of molecular interactions. Specifically, the competition between entropy and energy, and the ability of molecules to form specific, often weak, multivalent interactions, dictate whether phase separation occurs and how it is regulated.

Question: What governs the selectivity and dynamics of intracellular phase separation (membraneless organelles)?