• Question: how far is the HIV medicine have reached in terms of research

    Asked by dawn20fen to Sally, Mmboyi, Mike, Michael, Jacinta, Gliday, Elkana, Edna, Arnold on 17 Jul 2025.
    • Photo: Jacinta Nzilani

      Jacinta Nzilani answered on 17 Jul 2025:


      Hey,
      🌍 Latest Advances in HIV Medicine (2025), and since we are in Kenya, I will tell you some of the strides we are also making.
      🧬 1. Long-Acting HIV Prevention: Big Win for Kenya!
      In June 2025, the FDA approved Lenacapavir (brand name: Yeztugo), a revolutionary twice-yearly injectable for HIV prevention (PrEP).
      ✅ Scientific Breakthrough: It blocks the virus by targeting the HIV capsid – a new class of antiretroviral.
      ✅ Clinical Trials: Showed nearly 100% prevention rate in high-risk groups.

      Kenya is proudly among the first countries selected to receive and roll out Lenacapavir, alongside South Africa and Brazil, as part of an early access WHO-backed initiative. This marks a huge step toward ending new HIV infections, especially among young women and key populations.

      đŸ§Ș 2. Cure Research Highlights
      Broadly Neutralizing Antibodies (bNAbs) + immune boosters (like vesatolimod) are being tested in South Africa.
      🧠 Result: Some people stopped daily meds for over a year with no viral rebound, a step closer to remission.

      Gene editing (EBT-101) using CRISPR is in early human trials, aiming to cut out HIV DNA from infected cells.

      mRNA lipid nanoparticles developed in Australia are now being tested to flush out hidden HIV from the body.

      🧬 3. What’s Next for Kenya and Africa?
      Clinical trial sites in Kenya are being prepared to evaluate new long-acting combinations (e.g., capsid inhibitors + bNAbs).

      Education and access campaigns are underway to ensure high-risk populations benefit from these innovations early.

      💡 Bottom Line:
      Kenya is not just watching the science -we’re part of the breakthrough. With long-acting meds like Lenacapavir now in reach, and cure research advancing fast, the future of HIV care in Africa is looking brighter than ever. 🧡🌍

    • Photo: Michael Kimwele

      Michael Kimwele answered on 21 Jul 2025:


      Research on HIV medicine has advanced considerably, with long‑acting injectable prevention and treatment now in real-world use and several promising cure-oriented strategies emerging. Notably, in June 2025 the FDA approved lenacapavir (Yeztugo), a twice‑yearly injectable PrEP agent showing nearly 100% efficacy in trials—now endorsed by WHO and being rolled out globally, especially benefiting communities facing daily adherence challenges
      Reuters+14time.com+14labiotech.eu+14
      . For HIV cure research, cutting-edge breakthroughs include an mRNA-based “kick and kill” nanoparticle (LNP X) developed in Australia that unveils hidden HIV in immune cells—widely hailed as the most promising near-cure approach yet, though clinical trials are still years away
      reddit.com+4theguardian.com+4nypost.com+4
      . In parallel, CRISPR-based gene editing with Excision BioTherapeutics’ EBT‑101 has entered early human trials and shown safety, though full viral eradication in people remains unproven
      en.wikipedia.org+5hugcares.org+5aids.org+5
      ; and several stem‑cell transplant cases and combination immunotherapy trials have achieved sustained ART‑free remissions in small cohorts, suggesting functional cures may be achievable in specialized settings
      healthconnectdaily.com+15medosishealth.com+15hugcares.org+15
      .

      Overall, while antiretroviral therapy (ART) continues to control the virus for the vast majority living with HIV, the field is rapidly moving toward both improved long-acting prevention and real potential for cure, though widespread deployment of curative strategies remains years off.

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